GH-releasing hormone

B16. van den Berghe, G., de Zegher, F Veldhuis, J. D., Wouters, P Awouters, M Verbruggen, W., Schetz, M Verwaest, C Lauwers, R, Bouillon, R and Bowers, C. Y., The somatotropic axis in critical illness Effect of continous growth hormone (GH)-releasing hormone and GH-re-leasing peptide-2 infusion. J. Clin. Endocrinol. Metab. 82,590-599 (1997). 

Effects of recombinant human growth hormone (GH) on bone and intermediary metabolism in patients receiving chronic glucocorticoid treatment with suppressed endogenous GH response to GH-releasing hormone. J Clin Endocrinol Metab 1995 80(l) 122-9. 

Regulation of growth harmone (GH) secretion in mammals involves a complex interaction between inhibitory (somatostatin) and stimulatory (GH releasing hormone GHRH) neuropeptides synthesized and released by neurosecretory neurons terminating in the median eminence (Tuomisto and Mannisto, 1985 McMahon et al., 2001). Somatostatin and GHRH are transported in the hypophysial portal blood to the anterior pituitary... 

The anterior pituitary releases GH in 6 to 8 pulsatile bursts over a 24 h period the major portion is released just prior to deep sleep. Its secretion is controlled by hypothalamic peptides GH-releasing hormone stimulates GH secretion, while somatostatin inhibits it. GH stimulates the synthesis of insulin-like growth factor-1 (IGF-1 somatomedin C) mainly, but not solely, in the liver. GH and IGF-1 receptors are widely scattered throughout the body, and both hormones exert important metabolic actions in various tissues, especially muscle and bone. 

GH Releasing Hormone (GHRH) 44 (5,040) 20 TIDA (Arcuate, VMN) Stimulates GH secretion Gsa-AC activation... 

Martha, P.A. Jr, R.M. Blizzard, J.A. McDonald, M.O. Thorner A.D. Rogol. 1988. A persistent pattern of varying pituitary responsivity to exogenous growth hormone (GH)-releasing hormone in GH-deficient children Evidence supporting periodic somatostatin secretion. J. Clin. Endocrinol. Metab. 67 449-54. 

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