Gentamicin sulfate ointment

Melt items 2, 3, and 5 at 70°C in a small container using water bath. Put the melt under homogenizer (keep homogenizer warm to avoid losses caused by sticking). 

Dissolve item 1 in item 7 and heat to 50°C in water bath. Add step 2 to step 1 and homogenize for 2-3 minutes using homogenizer. Maintain the temperature around 50°C. 

Load item 6 in a fat-melting vessel while stirring at 70°C. Transfer the molten mass through filter to mixer and cool it down to 50°C. Note 

Rinse the homogenizer with warm item 4 and transfer the rinsing to the mixer. 

Cool the ointment to 30°-35°C with stirring under vacuum 0.4-0.6 bar. 

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Creams, ointments, and solutions containing 0.1-0.3% gentamicin sulfate have been used for the treatment of infected burns, wounds, or skin lesions and the prevention of intravenous catheter infections. Topical gentamicin is partly inactivated by purulent exudates. Ten mg can be injected subconjunctivally for treatment of ocular infections. 

Pred-G ophthalmic suspension 1% prednisolone acetate and gentamicin sulfate equiv. to 0.3% gentamicin base, Pred-G S.O.P. ophthalmic ointment 0.6% prednisolone acetate and gentamicin sulfate equiv to 0.3 gentamicin base)... 

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