Genotype, leukemia cell

B cell neoplasms based on morphology, immunophenotype, and genotype often, but not always, correspond to stages of B cell development. However, some B cell lymphomas either do not clearly correspond to a specific developmental stage (i.e., appear to be of variable origin such as chronic lymphocytic leukemia/small lymphocytic lymphoma) or do not appear to be related to any known stage of normal development (i.e., hairy cell leukemia) (H10). 

K20. Knowles, D. M., 2nd. The human T-cell leukemias Clinical, cytomorphologic, immunophenotypic, and genotypic characteristics. Hum. Pathol. 17, 14—33 (1986). 

Gronbaek K, Nedergaard T, Andersen MK, et al. Goncurrent disruption of cell cycle associated genes in mantle cell lymphoma a genotypic and phenotypic study of cyclin Dl, pl6, pl5, p53 andpRb. Leukemia. 1998 12(8) 1266-1271. 

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