Genomics applications

Genomics Applications that Facilitate the Understanding of Drug Action and Toxicity... 

M.J. Heller, A.H. Forster, and E. Tu, Active microelectronic chip devices which utilize controlled electrophoretic fields for multiplex DNA hybridization and other genomic applications. Electrophoresis 21, 157-164 (2000). 

There are six ribozymes that have been successfully modified and/or adapted for use in therapeutic and functional genomic applications. These are the group I introns, RNAse P, the hammerhead and hairpin motifs, the hepatitis delta ribozyme and the reverse splicing reaction of group II introns. Each of these ribozymes requires a divalent metal cation for activity (usually Mg++), which may participate in the chemistry of the cleavage/ligation reaction and/or may be important for maintaining the structure of the ribozyme. 

In recent years, there have been major technical advances in genetic analysis methods due primarily to use of new technologies developed for genomic applications. This is leading to an increased emphasis on faster, more efficient methods of detecting genetic mutations facilitated by the use of novel methods and equipment, with increased automation to reduce labor intensive steps in genetic analysis. 

The HOPGENE Program for Genomic Applications provides expressionprofiling data for many human diseases and animal models of human disease, (http //microarray.cnmcresearch.org/pgadatatable.asp)... 

It is one of eleven Programs for Genomic Applications (PGAs) funded by the National Heart, Lung and Blood Institute (NHLBI) of the NIH. The CardioGenomics PGA Public Data (http //cardiogenomics.med.harvard. edu/public-data.tcl) provides microarray data on a number of cardiac-related disease topics. 

Primrose, S.B. and Twyman, R.M., 2004, Genomics Applications in human biology, Blackwell Publishing (216 pages, paperback). 

---