Genomic Rearrangement

Golden, J. W., Mulligan, M. E. and Haselkorn, R. (1987) Different recombination site specificity of two developmentally regulated genome rearrangements. Nature, 327, 526-9. 

RNAi plays a key role in cellnlar defense against viral infection, genome rearrangement, the timing of developmental events, and brain morphogenesis. ... 

Taken together, these diverse data suggest that a high rate of non-meiotic genome rearrangement occurs in 5. mansoni. Whether this is a result of, or the driving mechanism behind, the relatively recent radiation of African Schistosoma species (Le et al., 2001b Lockyer et al., 2003) remains to be determined, as do the mechanisms responsible. 

Lee, J.A. and Lupski, J.R., Genomic rearrangements and gene copy-number alterations as a cause of nervous system disorders, Neuron, 52(1), 103, 2006. 

It is also conceivable that cell lines could have developed all the chemical intricacies that would, in proper relation to each other, express all of the organs and the structural components of a macro-organism, guided only by genomic rearrangements to produce a stem cell. 

There are a large number of diseases that are caused by genomic rearrangements involving several genes and they are usually referred to as genomic... 

From studies done primarily in S. cerevisiae, it is clear that ectopic recombination events occur at frequencies that are high relative to mutation frequencies. These events, therefore, are likely to be important in concerted evolution and perhaps in other types of evolutionarily important processes (e.g., genome rearrangements). The genetic control of ectopic recombination as well as the effects of repeat size and/or sequence heterogeneity on the frequency and types of ectopic recombination are active areas of investigation. 

Goddard AD, Balakier H, Clanton M, et al. Infirequent genomic rearrangement and normal expression of the putative RBI gene in retinoblastoma tumors. Mol Cell Biol 1988 8 2082-91. 

Mohammed MS, Shaffer LG. Fluorescence in situ hybridization (FISH) for identifying the genomic rearrangements associated with three myelinopathies. Methods Molec Biol 2003 217 219-38. 

Montagna M, DaUa Pahna M, Menin C, Agata S, De Nicolo A, Chieco-Bianchi L, et al. Genomic rearrangements account for more than one-third of the BRCAl mutations in northern Italian breast/ovarian cancer families. Hum Molec Genet 2003 12 1055-61. 

Sayama M, Bork P (2001) Evolution of prokaryotic gene order genome rearrangements in closely related species. Trends Gen 17 10-13... 

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