Genomic number

Source Number of screened genomes Number of putative BVMOs Examples of genomes containing multiple BVMOs ... 

Cell Megabases in genome Number of ORFs % ORFs of known function0... 

Group surveyed Number of enzymes used Number of sites per genome Number of variable sites Nucleotides in variable sites Ref. ... 

Pregrowth in 0.5 mM FdUrd to reduce genome copy number Reduction of chloroplast protein synthesis with spectinomycin Reduction in chloroplast genome number and protein synthesis... 

Genome Number of ORFS Number of ORFS <150 residues Monssler Folding CPU time Threading CPU time Refinement CPI time ... 

Table 3.1. Lactic acid bacteria genomes, number of complete or partially complete sequences per genus. Summarized from http //www.ncbi.nlm.nih.

With the realization that there are only a limited number of stable folds and many unrelated sequences that have the same fold, biologically oriented computer scientists started to address what is called the inverse folding problem namely, which sequence patterns are compatible with a specific fold If this question can be answered, such patterns could be used to search through the genome sequence databases and extract those sequences that have a specific fold, such as the cx/p barrel or the immunoglobulin fold. 

Many clones must be created to be confident that the genomic library contains the gene of interest. The probability, P, that some number of clones, N, contains a particular fragment representing a fraction, f, of the genome is... 

The Human Genome Project is also vital to medicine. A number of human diseases have been traced to genetic defects, whose positions within the human genome have been identified. Among these are... 

So efficient is the automated dideoxy method that sequences up to 1100 nucleotides in length, with a throughput of up to 19,000 bases per hour, can be sequenced with 98% accuracy. After a decade of work, preliminary sequence information for the entire human genome of 2.9 billion base pairs was announced early in 2001- Remarkably, our genome appears to contain only about 30,000 genes, less than one-third the previously predicted number and only twice the number found in the common roundworm. 

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