Genomic chaos

S. Nicolay, E.-B. Brodie of Brodie, M. Touchon, Y. d Aubenton-Carafa, C. Thermes, and A. Arneodo, Erom scale invariance to deterministic chaos in DNA sequences towards a deterministic description of gene organization in the human genome. Physica A 342,270-280 (2004). 

Chao YC, Hamblin M, Wood HA (1990), Physical map of Hz-1 baculovirus genome from standard and defective interfering particles, J. Gen. Virol. 71 1265-1270. 

Anti-viral drugs use mechanisms that interfere with nucleic acid and protein synthesis, inhibiting their attachment to and penetration of host cells. Because the viruses frequently adapt their structures, their elimination is difficult. A research team in Cambridge19 are looking at what they call a mutator protein . This protein is made by our own cells and is released to sneak inside certain viruses and cause chaos and mutations in their genome. Unfortunately the AIDS virus has evolved a defence against this process, but it is useful for other viruses. 

Wang, T.C., Chao, M. Molecular cloning and expression of the hepatitis delta virus genotype II b genome. Biochem. Biophys. Res. Comm. 

Brudno, M., Steinkamp, R., and Morgenstern, B. (2004) The CHAOS/DIALIGN WWW server for multiple alignment of genomic sequences. Nucleic Acids Res. 32, W41-W44. 

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