Genomic binding sites

Iyer V R, Horak C E, Scafe C S, et al. (2001). Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF. Nature. 409 533-538. 

Lee R., Kaushik N., Modak M.J., Vi-NAYAK R., Pandey V. N. Polyamide nucleic acid targeted to the primer binding site of the HlV-1 RNA genome blocks in vitro HlV-1 reverse transcription. Biochemistry 1998 37 900-910. 

Kaushik N., Talele T.T., Monel R., Palumbo P., Pandey V.N. Destabilization of tRNA3Lys from the primer-binding site of HIV-1 genome by anti-A loop polyamide nucleotide analog. Nucleic Acids Res. 2001 29 5099-5106. 

It should be possible to extend the DNA microarray-binding experiment to whole-genome analysis of transcription factor binding sites. The authors suggest that a microarray spotted with 12,000 one-kilobase sequences would span the entire Saccharomyces cerevisiae genome (Bulyk et al., 2001). Such an array could be used to characterize the sequence specificity of S. cerevisiae transcription factors. These experiments would be useful for predicting functions of previously uncharacterized transcription... 

The label putative is used in the DE line of proteins that exhibit limited sequence similarity to characterized proteins. These proteins often have a conserved site, e.g., ATP-binding site but no other significant similarity to a characterized protein. It is most frequently used for sequences from genome projects. Example ... 

---