Genetically engineered rats

Murakami, H., Yabusaki, Y., Sakaki, T., Shibata, M. Ohkawa, H. (1987). A genetically engineered P450 monooxygenase construction of the functional fused enzyme between rat cytochrome P450c and NADPH-cytochrome P450 reductase. DNA, 6, 189—97-... 

Sakaki,T., Kominami, S., Takemori, S., Ohkawa, H., Akiyoshi-Shibata, M. Yabusaki, Y. (1994). Kinetic studies on a genetically engineered fused enzyme between rat cytochrome P4501A1 and yeast NADPH-P450 reductase. Biochemistry, 33, 4933-9. 

Harvard researchers used genetic engineering techniques to produce rat insulin. 

Hobbs SM, Jackson LE, Hoadley J. Interaction of aglycosyl immunoglobulins with the IgG Fc transport receptor from neonatal rat gut comparison of deglycosyl-ation by tunicamycin treatment and genetic engineering. Mol Immunol 1992 29(7-8) 949-56. 

Bolon B, Galbreath E, Sargent L, Weiss J. Genetic engineering and molecular technology. In Krinke G, ed. The Laboratory Rat. London Academic Press, 2000 603-34. 

Levivier, M., Przedborski, S., Bencsics, C., and Kang, U. J., Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson s disease, J. Neumsci., 15, 7810, 1995. 

Frim, D.M., Uhler, T.A., Galpern, W.R., Beal, M.F., Breake-field, X.O. and Isacson, O. (1994) Implanted fibroblasts genetically engineered to produce brain derived neurotrophic factor prevent 1 methyl 4 phenylpyridinium toxicity to dopaminergic neurons in the rat. Proc. Natl. Acad. Sci. USA 91 5104-5108. 

Benoit, G.G., C.F. Naud, M.A. Simard, and A.L. Astier (1997). Noninterference of cytochrome P4501A2 in the cytotoxicity of tacrine using genetically engineered V79 Chinese hamster cells for stable expression of the human or rat isoform and two human hepatocyte cell lines. Biochem. Pharmacol. 53, 423-427. 

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