Genetic fingerprint theory

Benzene and its metabolites have long been known to cause chromosomal aberrations of various types of cell cultures of exposed humans. (To be discussed in Chapter 20.6 in fliis book entitled as Benzene Exposure and Sister Chromatoid Changes.) While it is true fliat genetic changes have been described and frequently effect chromosomes 5 and 7, and ofli-ers, there is no scientific evidence that these are required for the diagnosis of benzene exposure related cancers. Specifically, many cases of patients who have been exposed to 

1 NIOSH, Revised Recommendation for Occupational Exposure Standards for Benzene, Cincinnati, OH, DHEW Publications (NIOSH), 76-76-137-A (1976). 

2 Fishbein L, Scan J Work Environ Health, 8, Supplement 1, 5-16 (1992) 

3 ATSDR Toxicological Profile for Benzene- Update, U.S. Department of Health Human Services, Atlanta, Georgia (1996) 

4 Browning E. Toxicity and Metabolism of Industrial Solvents, Amsterdam, Elsevier Publishing, Chapter 1 (1965) 

17 Maltoni C, Myths and Facts in the History of Benzene Carcinogenicity in Advances in Modem Environmental Toxicology, Volume IV, M. Mehlman (Ed). Princeton Scientific Publishing Company, Princeton, 1-15 (1983) 

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