Genetic code engineering

Budisa N. Prolegomena to future experimental efforts on genetic code engineering by expanding its amino acid repertoire. Angew. Chem. Int. Ed. Engl. 2004 43 6426-6463. 

Prospects of genetic code engineering using unconventional amino acids 04AG (E)6426. 

GENESEQ GENESIS Gene therapy Genetic code Genetic colonization Genetic engineering... 

Nediljko B., Engineering the Genetic Code Expanding the Amino Acid Repertoire for the Design of Novel Proteins, Wiley, New York, 2006. 

Budisa N (2006) Engineering the genetic code expanding the amino acid repertoire for the design of novel proteins. Wiley-VCH, New York... 

Proteins Structure, Function, and Stability Expanding the Genetic Code Through Chemical Biology Synthetic Proteins, Design and Engineering of Phage Display... 

Budisa, N. (2006) Engineering the Genetic Code, Weinheim Wiley-VCH Verlag GmbH. 

For some considerable time, it was thought that the genetic code was universal, especially because genetic-engineering experiments showed repeatedly that eukaryotic genes could be expressed in bacteria such as E. coli. More recently, however, it has been found that mitochondria have their own genetic code and protein-synthetic machinery. This has led to discussions about the evolutionary origin of mitochondria, a topic that cannot be pursued here. 

Biotechnological stability also viewed as the ability of the genetically engineered cell line to resist mutation. Such a mutation may result in a change of the genetic code for a protein, thereby producing a protein with a modified amino acid sequence rather than the desired sequence. 

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