Generally schedule development

Physical realizability is often the most difficult of the above three corollary questions to answer. In general, to answer this question it is necessary to know 1) whether the materials and components required by the engineering design are available and 2) whether the manufacturing (and/or fabrication) techniques and skilled craftsmen needed to fabricate the product are also available. These two assessments are difficult to make because they often involve the projection of future technological developments. Technological developments usually do not occur according to schedule. 

Visual aids are developed from the planning schedule, in that assets and asset numbers are repeated and service visits indicated by a symbol. Hence, the estimated manhours for the specific task per frequency are not displayed for general review. 

The classification in Figure 8.3 shows that there is a tremendous diversity of factors that must be accounted for in short-term scheduling making the task of developing unified general methods quite difficult. At the same time, there is the trade-off of having a number of specialized methods that can address specific cases of this classification. 

The preclinical knowledge base is initially developed by designing studies to answer fundamental questions. The development of this knowledge base is generally applicable to most pharmaceuticals as well as biopharmaceuticals, and include data to support (1) the relationship of the dose to the biological activity, (2) the relationship of the dose to the toxicity, (3) the effect of route and/or schedule on activity or toxicity and (4) identification of the potential risks for subsequent clinical studies. These questions are considered in the context of indication and/or disease state. In addition there are often unique concerns related to the specific category or product class. 

Petroleum refining is a central and crucial link in the oil supply chain and has received extensive attention over the last decades. However, despite all the progress that has been made in developing planning and scheduling models, a general... 

Our next staff development seminar is scheduled for 8/7/01. We plan to discuss the modification requirements for general education teachers. 

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