Generalization of the Presenting Protein Strategy

Using a Presenter Protein to Enhance the Affinity of a Small Molecule Ligand Toward a New Approach to Enhance Drug-Target Interactions 

A good presenter protein should be expressed at high levels in the same cell as the drug target. It should have a high-affinity, cell-perme- 

Enhancing the Affinity of an SH2 Domain Ligand with a Presenter Protein 

The important role of SH2 domains in many signaling pathways, makes them ideal candidates for therapeutic intervention. In order to 

The phosphatase calcineurin plays a critical role in many different physiological systems. After the initial elucidation of the central role this enzyme plays in the immune system, it has recendy been implicated in synaptic plasticity and other neuronal processes, in cardiac valve development, and even in cardiac hypertrophy. The later is a disease process for which a calcineurin-regulated pathway may be a good site for therapeutic intervention. In all of these systems, the calcineurin 

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CALCINEURIN INHIBITORS AND THE GENERALIZATION OF THE PRESENTING PROTEIN STRATEGY... 

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