General Practice Research Database GPRD

In a matched nested case-control study using data from the UK General Practice Research Database (GPRD) there were 875 cases of a lupus-like syndrome, of which 12% ( = 107) had evidence of a prescription for one or more of the suspected drugs, and they were compared with 3632 matched controls [68 ]. There was an increased risk of lupus-like syndrome with hydralazine (OR = 6.6, 95% CI = 1.03, 43), minocycline (OR = 4.2, 95% Cl = 2.7, 6.8) and carbamazepine (OR = 1.9, 95%... 

In a study based on the UK General Practice Research Database (GPRD) in patients with ADHD, aged 2-21 years, from 1993 to 2006 with prescriptions for methylphenidate, dexamfetamine, or atomoxetine, there was no increase in the risk of sudden death but there was an increased risk of suicide [55 ]. Seven patients died in a cohort of 18 637 patient-years, and cause of death was obtained in six none was deemed to be a case of sudden death (incident rate ratio 1.63 95% Cl = 0.04, 9.71). The standardized mortality ratios for suicide were 162 (95% Cl = 20, 585) in patients aged 11-14 years and... 

Skin Lithium is associated with an increased risk of psoriasis [76, 77 ]. In a 10-year database study using the UK-based General Practice Research Database (GPRD) 36 702 subjects with psoriasis were compared with an equivalent matched group without psoriasis long-term use of lithium (five or more prescriptions) was... 

Observational studies In a survey of the adverse effects of strontium ranelate using the UK General Practice Research Database (GPRD), age-adjusted rate ratios for certain adverse reactions were [49 ] ... 

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