Gene Mapping and Cloning

An important step in understanding the basis of an inherited disease is to locate the gene(s) responsible for the disease. This chapter provides an overview of the techniques that have been used to map and clone thousands of human genes. 

A crossover event occurs between ioa A and B, producing a recombination of alleles in the chromosomes transtn ed to an offspring. 

Loci B and C are more closely Bnlced. so the crossover does not produce a recombination of their aOeies. 

A haplotype designates the specific alleles of multiple loci on a single chromosome 

Alleles of lod that are dose together on the same chromosome are likely to be inherited together these lod are said to be linked. If two lod are on different chromosomes, or if they are far apart on the same chromosome, their aUdes will be transmitted independently. This means that if an allele at one locus is transmitted, there is a 50% chance (as in coin tossing) that a given allde at the other locus will also be transmitted. Linked loci are dose enough together so that the chance of a recombination is less than 50%. Thus, their inheritance is not independent. 

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V. GENETICS OF RIFAMYCIN PRODUCTION A. Gene Mapping and Cloning... 

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