Gene loss

Double receptor gene Loss of OXiR and OX2R... 

The sequence of events from mutations or damage to proto-oncogenes and leads to tumour suppressor genes, loss of development of cancer, with its metabolic disturbances and cachexia. Finally these changes can lead to... 

Adams KL, Palmer JD (2003) Evolution of mitochondrial gene content gene loss and transfer to the nucleus. Mol Phylogenet Evol 29 380-395 Adams KL, Daley DO, Qiu YL, Whelan J, Palmer JD (2000) Repeated, recent and diverse transfers of a mitochondrial gene to the nucleus in flowering plants. Nature 408 354-357... 

Gabaldon T, Huynen MA (2005) Lineage-specific gene loss following mitochondrial en-dosymbiosis and its potential for function prediction in eukaryotes. Bioinformatics 21 (2) iil44—iil50... 

Dynamics of Gene Gain and Gene Loss in Bacteria... 

Garcia-Fernandez, J., Tandeau de Marsac, N., and Diez, J. (2004). Streamlined regulation and gene loss as adaptive mechanisms in Prochlorococcus for optimized nitrogen utilization in oligotrophic environments. Microbiol. Mol. Biol. Rev. 68, 630—638. 

Krieg M, Haas R, Branch H, Acker T, Flamme I, Plate KH. Up-regulation of hypoxia-inducible factors HIE-1 alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function. Oncogene 2000 19 5435-5443. 

S gene loss of the a determinant (= absence of vaccine protection)... 

Pre-S gene loss of B and T cell epitopes or loss of the pre-S2 promoter region or loss of the pre-S2 start codon (= no neutralization of the virus by anti-HBs)... 

C gene loss of T cell epitopes (= tendency to fulminant hepatitis) so-called escape mutants... 

P gene loss of polymerase (= accelerated elimination of the virus, unfit mutant) so-called replication defect... 

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