Gene family characteristics

Both PL and LPL require cofactors for full expression of activity (CLP and apoC-11, respectively) no such cofactor is necessary for HL. Derewenda and Cambillau (1991) postulated that, in the human lipase gene family of enzymes, the loops of the N-terminal domain, which exhibit the most pronounced variation in their amino acid sequences, may be responsible for conferring specificity with respect to cofactors. The structure of the lipase-procolipase complex (van Tilbeurgh et al., 1992 see above) does not support this hypothesis. However, in the case of LPL the structural basis of its interaction with apoC-11 may be quite different. Wong et al. (1991) and Davis et al. (1992) produced hybrid molecules by interchanging the C-terminal domains between the rat hepatic and lipoprotein lipases. Their HL chimera, made up of the HL N-terminal catalytic domain and the LPL C-terminal fragment, exhibited the salt-resistant catalydc properties characteristic of HL, but was... 

Opposing Shifts in Family Characteristics upon Teleost/Tetrapod Transition in Two Olfactory Receptor Gene Families... 

The molluscum contagiosum members of the poxvirus (MCV) family characteristically induce nonin-flamed papular skin tumors in children and AIDS patients (Table 8). One of the MCV products acts as a broad-spectrum antagonist that blocks the response of a variety of leukocytes to both CXC and CC chemokines which may account for the failure of host inflammatory responses to MCV (Damon et al., 1998). This gene product also suppresses replication of hematopoietic progenitor cells (Krathwohl et al., 1997). 

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