Gene expression/regulation levels

Gene expression—cholesterol levels control the amount of mRNA. If [cholesterol] is high, levels of mRNA coding for the reductase are reduced. If [cholesterol] is low, more mRNA is made. (Regulation of gene expression is discussed in Chapter 31.)... 

The cAMP pathway is thought to play an important role in the gene expression regulated by the dopamine receptors. Indeed, many treatments that induce gene expression in the striatum are also known to increase cAMP levels. In the model of 6-OHDA-lesioned animal, gene induction was triggered by D1 agonist treatments or by l-DOPA via D1... 

Phosphorylation of HSF substantially enhances the transcriptional activity of HS gene expression which may be up to 100-fold of basal levels after HSFl binds to the promoter element. Heat shock will increase the C-terminal-domain-kinase activity in cell extracts, and this action may enhance the activity of RNA polymerase II that is bound to HS genes (Legagneux et al., 1990). Whether this kinase activity also affects HSFl phosphorylation is not known, but increased HS gene expression appears to occur as long as HSFl is bound to the promoter region. The CTD kinase complex contains multiple proteins, and it is quite possible that one or more of these proteins is also regulated by stress. 

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