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Gene expression genomic control

Given that HIV-1 retroviral DNA is integrated into the human genome and that cellular gene expression is controlled by local chromatin structure, viral transcription is likewise modulated by local chromatin structure. [Pg.375]

In the nuclei of all eukaryotic cells, DNA is tightly wrapped around an octamer of histone proteins and is compacted into a dense structure known as chromatin. In order to access the genetic information which is required in numerous essential cellular processes including DNA replication, gene expression and DNA repair, chromatin needs to be partially unwound. One important mechanism to regulate chromatin structure and thus to control the access of the genomic DNA is through histone modifications [1-6]. The histone octamer is composed of two copies of H2A, H2B, H3 and H4 core histone proteins. Their tails, that protrude out of the surface of the... [Pg.341]

DeRisi, J. L., Iyer, V. R. and Brown, P. O. (1997), Exploring the metabolic and genetic control of gene expression on a genomic scale , Science, 278, 680-686. [Pg.345]

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