Gene expression changes induced

Bareyre, F. M., Haudenschild, B. and Schwab, M. E. Long-lasting sprouting and gene expression changes induced by the monoclonal antibody IN-1 in the adult spinal cord. /. Neurosci. 22 7097-7110, 2002. 

Baker YA, Harries HM, Waring JF et al. Clofibrate-induced gene expression changes in rat liver a cross-laboratory analysis using membrane cDNA arrays. Environ Health Perspect 2004 112 428-438. Waring JF, Ulrich RG, Flint N et al. Interlaboratory evaluation of rat hepatic gene expression changes induced by methapyrilene. Environ Health Perspect 2004 112 439 48. 

Islaih M, Li B, Kadura IA, Reid-Hubbard JL, Deahl JT, et al. Comparison of gene expression changes induced in mouse and human cells treated with direct-acting mutagens. Environ Mol Mutagen 2004 44(5) 401-19. 

Gildea LA, Ryan CA, Foertsch LM, Kennedy JM, Dearman RJ, Kimber I, Gerberick GF. Identification of gene expression changes induced by chemical allergens in dendritic cells opportunities for skin sensitization testing. J Invest Dermatol 2006 126 1813-1822. 

Figure 13.9 Selected examples of scatter plots of gene expression changes induced by cationic polymers in A431 cells. Data represent Log2 transformed gene expression values. Above 2-fold change in expression of treated to untreated is indicated by reference lines, showing over-expressed genes (bold circles) and unchanged genes (unfilled circles). PF Polyfect bPEI branched polyethylenimine IPEI linear polyethylenimine (our unpublished data produced by Omidi et al).

Table 13.1 Gene expression changes induced by biodegradable poly(lactic-co-glycolic acid) (PLGA) in A431. T treated UT untreated. (Unpublished data produced by Omidi et al.).

Hammond TG et al. Mechanical culture conditions effect gene expression gravity-induced changes on the space shuttle. Physiol Genomics 2000 3 163-173. 

Betts, C J. et al., Temporal changes in cytokine gene expression profiles induced in mice by trimellitic anhydride. Tox. Lett., 136, 121, 2002. 

Antigen-induced, non immune response-related gene expression changes Immune response characteristics on gene expression level at 6 and 13 months, respectively ... 

D. Long-term metabolic responses, occurring over the course of hours or days, involve regulation of gene expression to induce changes in levels of one or more enzymes. 

Wlodarczyk BJ et al (2006) Arsenic-induced gene expression changes in the neural tube of... 

Szczesna-Skorupa E, Chen CD, Liu H, Kemper B. Gene expression changes associated with the endoplasmic reticulum stress response induced by microsomal cytochrome p450 overproduction. J Biol Chem 2004 279 13953-13961. 

Lin YL, Lee SS, Lou SM, Chiang BL. Polysaccharide purified from Ganoderma lucidum induces gene expression changes in human dendritic cells and promotes T helper 1 immune response in BALB/c mice. Mol. Pharmacol. 2006 70 637-644. 

Increased hundngtin protein lengtli reduces tlie severity of polyglutamine-induced gene expression changes in mouse models of Huntington Disease. Hum Mol Genet 11 1939-1951. 

Chen H, Huang XN, Stewart AF ct al. Gene expression changes associated with fibronectin-induced cardiac myocyte hypertrophy. Physiol Genomics 2004 18(3) 273-283. 

Figure 15-4 In silico subtraction method for mechanistic study to compare the hepatic gene expression profile induced by compound X to other compounds that induce hepatic APR secondary to inflammation at sites other than the liver. In the proposed simple model, compound X-induced gene expression change has two components. One is vasculitis specific the other is acute phase response (APR) specific. By subtracting the APR specific component, we might select candidate genes that are specifically associated with the hepatic vascular lesion Diclofenac known to induce APR without triggering vasculitis in liver is used to subtract genes activated by hepatic APR from the compound X response.

In contrast to arARs, the effects of a2-AR stimulation on gene expression have not been well studied with DNA microarrays. Laifenfeld et al. (50) used DNA microarrays to identify gene expression changes that accompany norepinephrine-induced neuronal differentiation in SH-SY5 Y cells that endogenously express o -ARs. However, much more work is needed to understand fully the effects of (Xj-AR stimulation on gene expression. 

Yamazaki K, Kuromitsu J, Tanaka I (2002) Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator-activated receptor alpha agonists. Biochem Biophys Res Commun 290 1114-1122... 

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