Gene-diet interactions

Gene-Diet Interactions, Blood Lipids, and Cardiovascular Disease Risk The Rise of Nutrigenetics... 

GENE-DIET INTERACTIONS, BLOOD LIPIDS. AND CARDIOVASCULAR DISEASE... 

Lyon Diet Heart Study, achieved >70% reduction in CAD events (5), evidence for the existence of other major targets that should be addressed. This short review examines recent paradigm shifts and advances in atherosclerosis research that are likely to influence the future of dietary intervention aimed at preventing CAD. It will consider in turn the shift of emphasis toward unstable plaques, inflammation, oxidative processes, and endothelial dysfunction, as well as the growing interest in gene-diet interactions. 

Ordovas, J.M. (2002) Gene-Diet Interaction and Plasma Lipid Responses to Dietary Intervention, Biochem. Soc. Trans. 30.68-73. 

Campos, H., D Agostino, M., and Ordovas, J.M. (2001) Gene-Diet Interactions and Plasma Lipoproteins Role of Apolipoprotein E and Habitual Saturated Fat Intake, Genet. Epidemiol. 20, 117-128. 

Chen J, Giovannucci EL, Hunter DJ. MTHFR polymorphism, methyl-replete diets, and the risk of colorectal carcinoma and adenoma among U.S. men and women an example of gene-environment interactions in colorectal tumorigenesis. J Nutr 1999 129(Suppl 2) 560S-564S. 

In this chapter, we explore how genetic variations identified in samples from large population-based studies are beginning to provide hints about gene-diet and gene-environment interactions that may lead to more individualized recommendations for preventing cardiovascular disease. 

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