Gene-deficient mice

Immune expulsion of T. spiralis is clearly Th2- and, specifically, IL-4-dependent. However, contrary to expectations, enteropathy (as assessed by changes in villus/crypt ratios) is regulated by IL-4 and not IFN-y (Lawrence et al., 1998). Moreover, the usual severe pathology is not induced in p55 TNF receptor (TNF-R1) gene-deficient mice, which nevertheless expelled... 

DeLorey, T. M., and Olsen, R. W. (1999) GABA and epileptogenesis comparing gabrb3 gene-deficient mice with Angelman syndrome in man. Epilepsy Res. 36, 123-132. 

GABRB3 Gene Deficient Mice A Potential Model of Autism Spectrum Disorder Timothy M. DeLorey... 

Chen C, Liu X, Smith BJ. Utility of Mdrl-gene deficient mice in assessing the impact of P-glycoprotein on pharmacokinetics and pharmacodynamics in drug discovery and development. Curr Drug Metab 2003 4(4) 272-291. 

Chen C, Pollack GM. Altered disposition and antinociception of [D-penicillamine (2,5)] enkephalin in mdrla-gene-deficient mice. J Pharmacol Exp Ther 1998 287 (2) 545-552. 

Pass J, Joggi A, Lund IK, Rono B, Rasch MG, Gardsvoll H, et al. Murine monoclonal antibodies against murine uPA receptor produced in gene-deficient mice Inhibitory effects on receptor-mediated uPA activity in vitro and in vivo. Thromb Haemost 2007 97(5) [in press]. 

Carmeliet P, Schoonjans L, Kieckens L et al. (1994) Physiological consequences of loss of plasminogen activator gene function in mice. Nature 368 419-424 Carmeliet P, Stassen JM, Schoonjans L et al. (1993) Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, thrombolysis. J Clin Invest 92 2756-2760... 

Zong J, Pollack GM. 2000. Morphine antinociception is enhanced in mdrla gene-deficient mice. Pharm. Res. 17(6) 749-53... 

DeLorey TM, Sahbaie P, Hashemi E, Homanics GE, Clark JD (2008) Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules a potential model of autism spectrum disorder. Behav Brain Res 187 207-220. 

MX gene-deficient mice were born and grew to adulthood without illness, but MX null males were infertile (59). The testes of MX null males were smaller than those of wild-type or heterozygous littermates. Electron microscopy showed prominent intercellular spaces surrounding MX null spermatocytes, suggesting a failure of germ cell adhesion to Sertoli cells within the seminiferous tubules. 

Statl can be activated by many cytokines. However, the generation of gene-deficient mice demonstrated that Statl is nonredundant in IFN-y and IFN-a/p responses (3,4). In the absence of Statl, the IFNs lose the ability to induce various genes and Statl-deficient mice become extremely susceptible to viral and bacterial infections during which IFN responses are important for host defense. 

Endothelial nitric oxide synthase gene-deficient mice (eNOS-/-) demonstrated marked retardation in postnatal bone formation, reduced bone volume, and defects in osteoblast maturation and activity (Aguirre et al. 2001). 

Gene-deficient mice. Gene-deficient mice are also called knockout mice. They are genetically engineered mice in which a certain gene has been disrupted... 

Boelens, J., Van Der Poll, T., Zaat, S., Murk, J., Weening, J., Dankerf J., 2000b. Interleukin-1 receptor type I gene-deficient mice are less susceptible to Staphylococcus epidermidis biomaterial-associated infection than are wild-type mice. Infect Immun. 68, 6924-6931. 

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