Gene activator protein

However, the a helices are not packed against each other in the usual way as described in Chapter 3. Instead, a helices 2 and 3, residues 15-36, form a unique helix-turn-helix arrangement that in 1981 had only been observed once, in a different bacterial DNA-binding protein, the catabolite gene-activating protein CAR... 

Weber, L, Steitz, T.A. The structure of a complex of catabo-lite gene activator protein and cyclic AMP refined at 2.S A resolution. /. Mol. Biol. 198 311-326, 1987. 

Schultz, S. C., Shields, G. C. and Steitz, T. A. (1990). Crystallization of Escherichia coli cataboUte gene activator protein with its DNA binding site. The use of modular DNA. /. Mol Biol 211,159-166. 

CAP catabolite gene activator protein GSSG glutathionine disulfide... 

CAP. The catabolite gene activator protein, sometimes incorrectly referred to as the CRP protein. The latter term, in small letters (crp), should be used to refer to the gene but not to the protein. 

McKay, D. B., and Steitz, T. A. (1981). Structure of catabolite gene activator protein at 2.9 A resolution suggests binding to left-handed B-DNA. Nature 290, 744—749. 

Know the roles of a regulator gene, repressor and corepressor, catabolite gene activator protein (CAP), cyclic AMP, and attenuator. 

Recall that the lacl, crp, and cya genes encode the Lacl repressor protein, the catabolite gene activator protein, and adenylate cyclase, respectively. 

Catabolic Gene-Activator Protein (CAP) Positively Regulates the lac Operon... 

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