Gates molecular mechanisms

Catterall WA (2000) From ionic currents to molecular mechanisms the structure and function of voltage-gated sodium channels. Neuron 26 13-25... 

A prerequisite for this model is the existence of both external and internal gates, i.e., protein domains that are capable of occluding access to the substrate binding site from the extracellular and intracellular environment, respectively. Little is known about such domains in this family of transporters. The molecular mechanisms governing the cooperative function of the putative gating domains also remain unknown. It could be predicted, however, that stabilization of the transporter in the outward-facing conformation in the absence of substrate but in the presence of Na+ requires a network of con-... 

To accommodate the effects on the activated brain of pulling it off-line with respect to its external inputs and outputs, and to recognize the fact that this gating does not parallel the electrical activation of the brain in REM, I have assigned the second dimension of the three dimensional AIM model, the dimension I, to input-output gating. In the case of factor I, we have an elaborately detailed picture of the cellular and molecular mechanisms that are called into play during REM sleep. 

Catterall WA. Molecular mechanisms of gating and drug block of sodium channels. Novartis Found Symp. 2002 241 206-218. 

The molecular mechanism of local anesthesia, the location of the local anesthetic dibucaine in model membranes, and the interaction of dibucaine with a Na+-channel inactivation gate peptide have been studied in detail by 2H- and 1H-NMR spectroscopy [24]. Model membranes consisted of PC, PS, and PE. Dibucaine was deuterated at H9 and H3 of the butoxy group and at the 3-position of the quinoline ring. 2H-NMR spectra of the multilamellar dispersions of the lipid mixtures were obtained. In addition, spectra of deuterated palmitic acids incorporated into mixtures containing cholesterol were obtained and the order parameter, SCD, for each carbon... 

Cestele S, Catterall WA (2000) Molecular mechanisms of neurotoxin action on voltage-gated sodium channels. Biochimie 82 883-892... 

Perozo E, Cortes DM, Sompornpisut P. Kloda A, Martinac B. Structure of MscL in the open state and the molecular mechanism of gating in mechanosensitive channels. Nature 2002 418 942-948a. 

Molecular mechanisms of gating and drug block of sodium channels... 

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