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Gastrointestinal tract swallowed drugs

The important stages in delivering a drug to its desired target after an oral dose can be summarized as shown in Fig. 6.2. Initially the formulation has to be swallowed and survive the transition to the site of absorption - the gastrointestinal tract (GIT). The time required for this to happen will depend on the stomach emptying time, which in turn will be a function of the fed/fasted state of the subject or animal that is being studied (see for example Ref. [7]). This kind of information can only be obtained from in vivo studies. [Pg.136]

Nystatin [nye STAT in] is a polyene antibiotic its structure, chemistry, mode of action, and resistance resemble those of amphotericin B. Its use is restricted to topical treatment of Candida infections because of its systemic toxicity. The drug is negligibly absorbed from the gastrointestinal tract, and it is never used par-enterally. It is administered as an oral agent ( swish and swallow ) for the treatment of oral candidiasis. Excretion in the feces is nearly quantitative. Adverse effects are rare because of its lack of absorption, but occasionally nausea and vomiting occur. [Pg.354]

Drugs intended for localized effects are generally applied direcdy to the intended site of action. These products include those intended for use in the eyes, ears, nose, and throat, as well as applied to the skin or placed into, on, or around the other body cavities. They may even be applied to the oral cavity or swallowed to treat any localized diseases within the gastrointestinal tract. [Pg.14]


See other pages where Gastrointestinal tract swallowed drugs is mentioned: [Pg.41]    [Pg.102]    [Pg.291]    [Pg.3]    [Pg.25]    [Pg.138]    [Pg.223]    [Pg.70]    [Pg.236]    [Pg.9]    [Pg.958]    [Pg.2426]    [Pg.1322]    [Pg.166]    [Pg.308]    [Pg.239]    [Pg.130]    [Pg.5]    [Pg.33]    [Pg.503]    [Pg.413]    [Pg.413]    [Pg.264]    [Pg.285]    [Pg.1298]    [Pg.233]    [Pg.19]    [Pg.144]   
See also in sourсe #XX -- [ Pg.107 ]




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