Gastrointestinal system irritable bowel syndrome

Irritable bowel syndrome (IBS) is a disorder of the gastrointestinal tract that interferes with the normal functions of the colon. At various points in the past, IBS has been referred to as mucous colitis, spastic colon, irritable colon, or nervous stomach. IBS is generally described as afunctional disorder rather than a disease per se. A functional disorder involves symptoms that cannot be attributed to a specific injury, infection, or other physical problem. A functional disorder occurs because of altered physiologic processes rather than structural or biochemical defects and may be subject to nervous system influence. IBS is associated with frequent fluctuation in symptoms, loss of productivity, and decreased quality of life. Although IBS has been referred to as functional bowel disease, true functional bowel disease may be more indicative of widespread gastrointestinal involvement including (but not limited to) the colon. 

Gastrointestinal System Drugs Irritable Bowel Syndrome... 

In particular, 1,7-annulated indole derivatives, such as the prototypical Cilansetron A, display high activity as 5-HT3 receptor antagonists and are being clinically tested for the treatment of symptoms in the gastrointestinal system such as the irritable bowel syndrome (IBS) [26]. To extend our previous synthetic strategy based on the reactivity of hydrazinediido zirconium complexes to annulated polycyclic indole derivatives, we aimed to prepare such hydrazides derived from cyclic hydrazines (B). 

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