Gastrointestinal system antacids

Gastrointestinal system. Antacids that contain large quantities of sodium can precipitate fluid retention to cause ascites. Aluminium- and Ccilcium-based preparations cause constipation and may thereby precipitate hepatic encephalopathy, as can antimotility drugs. 

Gastrointestinal system Carbenoxolone Cimetidine Amiloride, spironolactone Antacids Inhibition of ulcer healing. Reduced absorption if taken simultaneously. 

Gastrointestinal system Dysgeusia (unpleasant taste) was identified with higher daily doses of 500 or 750 mg [1,3,4], In a randomised crossover high-altitude study, one of the patients complained of dyspepsia while on oral acetazolamide (500 mg per day) at 1860 m who recovered after antacid therapy [2],... 

Antacids, antidiarrheals, and laxatives are considered topical drugs since they work in the gastrointestinal tract which is considered an extracellular body fluid. These drugs, when used correctly, are not appreciably absorbed through the intestinal wall and do not show systemic effects. 

Ketoconazole (Nizoral) has a broad therapeutic potential for a number of superficial and systemic fungal infections. Ketoconazole dissolves in an acidic media therefore, antacids or histamine2-receptor-blocking agents reduce its effectiveness (Figure 45.3). Ketoconazole can cause gastrointestinal disturbances. 

Cautions Safety in children less than 6 years is not known. Antacids Undiagnosed gastrointestinal or rectal bleeding, ulcerative colitis, colostomy, diverticulitis, chronic diarrhea. Laxative Diabetes mellitus or patients on low-salt diet (some products contain sugar and sodium). Systemic Severe renal impairment. 

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