Gastrointestinal irritation substances that cause

The major risk associated with use of ibuprofen is stomach irritation. The inventors of ibuprofen had hoped to find a substance that causes less stomach irritation than aspirin. Ibuprofen does seem to cause fewer gastrointestinal problems than does aspirin. Nevertheless, it can still cause severe problems in some patients, especially those who take large doses. Common complaints from the use of ibuprofen include nausea, stomach pain, and diarrhea. Patients who are especially sensitive or who take high doses of ibuprofen for long periods may experience damage to the stomach lining. 

---