Gastroesophageal reflux disease nonerosive

Richter, J. E., Campbell, D. R., Kahrilas, P. J., Huang, B., and Eludas, C. (2000) Lansoprazole compared with ranitidine for the treatment of nonerosive gastroesophageal reflux disease. Arch. Intern. Med. 160, 1803-1809. 

BE Barrett s esophagus ENRD endoscopy-negative reflux disease GERD gastroesophageal reflux disease LES lower esophageal sphincter NERD nonerosive reflux disease... 

In current clinical practice, many patients with symptomatic gastroesophageal reflux are treated empirically with medications without prior endoscopy, ie, without knowledge of whether the patient has erosive or nonerosive reflux disease. Empiric treatment with proton pump inhibitors provides sustained symptomatic relief in 70-80% of patients, compared with 50-60% with H2 antagonists. Due to recent cost reductions, proton pump inhibitors are increasingly being used as first-line... 

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