Gastroduodenal pathogen

H. pylori is a highly prevalent, bacterial gastroduodenal pathogen of humans infecting 50% of the world s population by 50 years of age (Kusters et al., 2006). 

Moran, A.P. Relevance of fucosylation and Lewis antigen expression in the bacterial gastroduodenal pathogen Helicobacter pylori. Carbohydr Res 343 (2008) 1952-1965. 

Rathbone, B.J. and Heatley, R.V. (1992). Possible pathogenic mechanisms in Helicobacter pylori infection. In Helicobacter pylori and Gastroduodenal Disease (eds. B.J. Rathbone and R.V. Heatley) pp. 217-223. Blackwell Scientific Pubhcations, Oxford. 

A number of bacterial and host factors contribute to the ability of HP to cause gastroduodenal mucosal injury. Pathogenic mechanisms include (a) direct mucosal damage, (b) alterations in the host immune/inflammatory response, and (c) hypergastrinemia leading to increased acid secretion. In addition, HP enhances the carcinogenic conversion of susceptible gastric epithelial cells. ... 

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