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Bombesin/gastrin-releasing peptide

Mokotoff M, Ren K, Wong LK, et al. Synthesis and biological evaluation of novel potent antagonists of the bombesin/gastrin releasing peptide receptor. J Med Chem 1992,35 4696-4703. [Pg.327]

IC5Q — 3.4 pM gastrin-releasing peptide/bombesin receptor... [Pg.7]

Semi-rational approaches Four subt)rpes of the bombesin receptor have been identified (gastrin-releasing peptide [GRP] receptor, neuromedin B receptor, the orphan receptor bombesin receptor subtype 3 and bombesin receptor subtype 4). The roles of individual receptor... [Pg.37]

Gastrin-releasing peptide (GRP) Extremely potent excitatory transmitter to gastrin cells. Also known as mammalian bombesin. [Pg.109]

Naldini, L., D. Cirillo, T. W. Moody, P. M. Comoglio, J. Schlessinger and R. Kris (1990). Solubilization of the receptor for the neuropeptide gastrin-releasing peptide (bombesin) with functional ligand binding properties. Biochemistry 29(21) 5153— 5160. [Pg.128]

Manzanares J, Edwards JV, Lookingland KJ, Moore KE (1994) MDL-101,562 blocks the stimulatory effects of bombesin and gastrin-releasing peptide on hypothalamic dopaminergic neurons. Eur J Pharmacol 257 199-202. [Pg.512]

Bombesin and related peptides such as gastrin-releasing peptide, neuromedin B and somatomedin are autocrine growth factors, anorexigenic and inducers of GI hormone (e.g. gastrin) release. Bombesin acts via Gaq to elevate cytosolic Ca2+. [Pg.165]

Brown M, Marki W, Rivier J. Is gastrin releasing peptide mammalian bombesin Life Sci. 1980 27 125-128. [Pg.2209]

Marki W, Spiess J, Tach6 Y, Brown M, Rivier JE. Total solid-phase synthesis of porcine gut gastrin releasing peptide (GRP), a mammalian bombesin. J. Am. Chem. Soc. 1981 103 3178-3185. [Pg.2209]

Gastrin receptor antagonists and gastrin-releasing peptide antagonists have now been developed for experimental use. but it is not yet clear if either will be useful clinically. See BOMBESIN RECEPTOR ANTAGONISTS) CHOLECYSTOKININ RECEPTOR ANTAGONISTS. [Pg.130]

Several other gut peptides such as en-terostatin or gastrin-releasing-peptide (and other bombesin-like peptides) are also involved in initiating satiation responses after food intake. The roles of these peptides in regulating food intake have been reviewed elsewhere (34). [Pg.873]

LA BELLA, R., et al., In vitro and in vivo evaluation of a Tc(I)-labelled bombesin analogue for imaging of gastrin releasing peptide receptor-positve tumours, Nucl. Med. Biol. 29 (2002) 553-560. [Pg.196]

Gastrin-Releasing Peptide(GRP) (mammalian Bombesin) 27 Stomach, duodenum Thermoregulation Nociception Gastrin release from G cells in stomach... [Pg.734]

See other pages where Bombesin/gastrin-releasing peptide is mentioned: [Pg.797]    [Pg.100]    [Pg.797]    [Pg.404]    [Pg.570]    [Pg.570]    [Pg.797]    [Pg.100]    [Pg.797]    [Pg.404]    [Pg.570]    [Pg.570]    [Pg.530]    [Pg.276]    [Pg.6]    [Pg.139]    [Pg.147]    [Pg.267]    [Pg.221]    [Pg.1750]    [Pg.110]    [Pg.127]    [Pg.66]    [Pg.187]    [Pg.188]    [Pg.473]    [Pg.477]    [Pg.138]    [Pg.276]    [Pg.294]    [Pg.447]    [Pg.2204]    [Pg.52]    [Pg.131]    [Pg.131]    [Pg.191]    [Pg.182]    [Pg.205]    [Pg.37]    [Pg.837]    [Pg.816]    [Pg.907]   
See also in sourсe #XX -- [ Pg.570 ]



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Bombesin

Gastrin

Gastrin-releasing peptide

Peptide releaser

Peptides release

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