Gastrin pentapeptide

Gastrin Pentapeptide ICI" 1-20 y/i Insulin from Rabbit Pancreas... 

Gastrin-pentapeptide from Imperial Chemical Industries, England, though somewhat less potent clearly induced release of insulin by the rabbit pancreas "in vitro", too (Fig.13). Wore details on the insulin stimulating action of these intestinal hormones are given elsewhere (Schroder et al (1967)). 

CCK-PZ 50 113-116), whose C-terminal pentapeptide sequence is identical with that of gastrin, is discharged into the blood from certain intestinal cells and reaches the gallbladder, where it causes the bile to discharge into the intestine, thus promoting digestion. Cholecystokinin also functions as a cerebral neurotransmitter. 

Barrett AM (1966) Specific stimulation of gastric acid secretion by a pentapeptide derivative of gastrin. J Pharm Pharmac 18 633-639... 

A synthetic derivative of an active fraction of gastrin, commonly referred to as the "gastrin-like pentapeptide" or ICI 0,123, has been further evaliaated in animals and humans and has been used as an investigational secretory stimulant. This pentapeptide (l) consists of the tetrapeptide unit, TryMetAspPheNHo, from the carboxyl end of the gastrin molecule, acylated on the tryptophan amino group with N-(tert-butyloxy-carbonyl)-g-alanine. ... 

CCK-peptides at high TFE concentrations are very similar to those of gastrin peptides of similar size both regarding the overall pattern and the intensities of the maxima. The latter spectra were attributed to 7-turns, and a folding of the C-terminal portion of gastrin into a helical structure in TFE had been confirmed by NMR analysis (67). The presence of the identical C-terminal pentapeptide in the CCK molecule makes it most reasonable to assume that the observed CD properties in aqueous TFE reflect a similar conformational state of this sequence portion in CCK, too. This would also compare well with the 3D structure determined for fIhr,Nle)-CCK-9 by NMR in aqueous DMSO since the relatively small conformational shift from a 3iq- to an a-helix could easily result from the strong a-helix inducing effect of TFE as solvent (80,81). 

Raper, J. Physiol. (London) 102, 115 (1943). Identity with pancreozymin Jorpes et at., Acta Chem Scand. 18, 2408 (1964). The C-terminal pentapeptide has been shown to be identical to that of gastrin and caerulein V, Mutt, J. E. 

The pentapeptide, pentagastrin, has replaced natural gastrin (a heptadeca-peptide) as a diagnostic agent that stimulates gastric secretion. This pentapeptide is butyloxycarbonyl-)8-Ala-Trp-Met-Asp-Phe-NH2. It can be administered as a snuff. 

Pentagastrin is a pentapeptide which represents the physiologically active portion of the gastrin molecule. It stimulates the... 

This chapter is beginning to be written. Chole-cystokinin is a single chain polypeptide with 33 amino acid residues. The elucidation of its sequence is in its early stages. However, a very interesting fact has already emerged the C-terminal pentapeptide of cholecystokinin is identical with that of gastrin. ... 

Serum albumin as at least two binding sites for oligopeptide analogs of gastrin. Irradiation of photoreactive derivatives of the pentapeptide X-GlyTrpMetAspPheNH2 = 4-azidobenzoyl, 2-nitro-5-azidobenzoyl, 4-acetylbenzoyl, and 4-benzoylbenzoyl) regylts in incorporation of up to two moles of derivative per mole protein. Irradiation of three of the derivatives in radiolabeled form in the acinar cell suspensions results in incorporation of label. 

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