Enzyme digestible hydrogels

Gastric Retention of Enzyme-Digestible Hydrogels in the Canine Stomach under Fasted and Fed Conditions... 

Shalaby, W.S. and Park, K. (1990) Biochemical and mechanical characterization of enzyme-digestible hydrogels. Pharm. Res., 7 816-823. 

Shalaby, W.S.W., W.E. Blevins and K. Park, In vitro said in raao studies of enzyme-digestible hydrogels for oral drug deMs ery, Journal of Controlled Release, 19 (1992) 131—144. 

CK Sim, K Park. Examination of drug release from enzyme-digestible swelling hydrogels. Proc Int Symp Controlled Release Bioact Mater 16 219-220, 1989. 

Park K. Enzyme-digestible swelling hydrogels as platforms for long-term oral drug delivery synthesis and characterization. Biomaterials 1988 9 435-441. 

Russian researchers (Valuev et al., 2001) have proposed as a protection from destruction of proteins in the digestive tract ovomucoid inhibitor included in the hydrogel. In the hydrogel also included insuhn. As a result, the mechanism of action, this involves the inhibition of proteolysis of insuhn due to neutralizing proteolytic enzymes and increasing the rate of diffusion of insuhn from the pjartides through the small intestine. Rapad diffusion provided by interaction of the carbohydrate bonds of the hydrogel and of the ovomucoid with of lectins intestinal mucosa. 

Among the other characteristics of biomaterials, the polymeric constituents are digested by enzymes that are then absorbed by living organs and, additionally, fat and ions cannot necessarily penetrate fieely into the natural hydrogels. 

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