Gastric Intrinsic Factor and Vitamin B12 Binders

For detailed information on intrinsic factor (IF) the reader is referred to the recent monograph on this subject by the reviewer, the bibliography of which includes over 1500 references (G20). Therefore only the most salient points will be discussed here. 

The work of the past 35 years has confirmed Castle s initial concept (C5-C10) of a principle in human gastric juice necessary for normal hematopoiesis (G2Q). Its lack in the gastric content of pernicious anemia patients was recognized, as early as 1929 (C5, C9), to be the essential defect leading to the development of pernicious anemia, through failure of the reaction between extrinsic factor, now known to be identical with vitamin B12, and intrinsic factor in normal human gastric juice. Other investigators confirmed that IF is formed by the fundus and body of the stomach in man (see G20) and by the pyloric end of the stomach in the hog (L2, M33), and that it is absent from saliva. 

1950 Hall et al. Spies et al. Extract from hog pyloric and duodenal mucosa 330 mg 

1951 Glass, Boyd, Rubinstein, and Svigals Glandular mucoprotein from normal gastric juice 50-200 mg 

1953 Glass and Boyd Intrinsic factor concentrate from hog gastric and duodenal mucosa 30-60 mg 

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