Gas chromatography-coupled mass spectrometry GC-MS

Several papers utilizing 3 mm probe capabilities were also published that delved into the area of protein structures. Hepatocyte nuclear factor 4 was studied by a group lead by Williams.155 It is interesting to note that a 2.7 A X-ray study showed a fatty acid in the pocket of HNF4y. Gas chromatography coupled mass spectrometry (GC/MS) and 3 mm NMR studies of extracts from purified HNF4x led to the identification of mixtures of saturated and crs-monounsaturated Ci4 to Qg fatty acids. Bertini and co-workers156 utilized 3 mm probe capabilities in the determination of the solution structure of CopC, a cupredoxin-like protein involved in copper homeostasis. 

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