Garlic Warfarin

Garlic Warfarin Increases effectiveness of warfarin, bleeding... 

Dose Initial 0.25 mg PO tid, wkly 10.25 mg/dose, to 3 mg max max 4 mg for RLS Caution [C, /-] Sev e CV, renal, or hepatic impair Contra Component allergy Disp Tabs SE Syncope, postural X BP, NA, HA, somnolence, dosed-related hallucinations, dyskinesias, dizziness Interactions t Risk of bleeding W/ ASA, NSAIDs, fevCTfew, garlic, ginger, horse chestnut, red clover, EtOH, tobacco t effects OF amitriptyline, Li, MTX, theophylline, warfarin t risk of photosensitivity W/ dong quai— use sunscreen, St. John s wort X effects W/ antacids, rifampin X effects OF ACEIs, diuretics EMS t Bleeding risk w/ concurrent EtOH, tobacco, ASA, and NSAID use t effects of warfarin OD May cause N/V, drowsiness, hypotension, and CP symptomatic and supportive... 

Warfarin A brief case report described an increased clotting time in two patients taking warfarin and garlic garlic alone has also been associated with bleeding (case reports). 

Because of reported antiplatelet effects, patients using anticlotting medications (eg, warfarin, aspirin, ibuprofen) should use garlic cautiously. Additional monitoring of blood pressure and signs and symptoms of bleeding is warranted. Garlic may reduce the bioavailability of saquinavir, an antiviral protease inhibitor, but it does not appear to affect the bioavailability of ritonavir. 

Warfarin Garlic (Allium sativum) Increased INR Postoperative bleeding and spontaneous spinal epidural hematoma have been reported with garlic alone garlic causes platelet dysfunction... 

Garlic Hypertension, hypercholesterolemia Gastrointestinal upset, gas, reflux, nausea, allergic reactions, and antiplatelet effects. May effect warfarin (increase INR)... 

Garlic ASA, NSAIDs Clopidogrel, ticlopidine Warfarin Additive antiplatelet effects Additive antiplatelet effects Increased risk of bleeding... 

Vaes, L.P.J. Chyka, P.A. Interactions of warfarin with garlic, ginger, ginkgo, or ginseng nature of the evidence. Ann. Pharmacother. 2000, 34 (12), 1478-1482. 

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