Garcinol antioxidative activity

Recently garcinol (46), also called camboginol, has attracted considerable interest because of its associated beneficial health properties, including antiulcer activity [59], anti-glycation activity [60], cancer chemopreventive activity against colonic aberrant crypt foci (ACF) in an animal model [63], induction of apoptosis through cytochrome c release and activation of caspases in human leukemia cells [61]. It also showed strong antioxidant activity [59,60]. 

Krishnamurthy [73] observed that garcinol had no antioxidative activity in lipid peroxidation. Yamaguchi et al. evaluated the chelating, antioxidative and radical scavenging activities of garcinol, demonstrating that it has a strong antioxidant activity [59,60],... 

Their confirmed these results in the mycellar system [60]. Garcinol exhibited weak antioxidative activity in measurement of lipid peroxidation in mycellar system, being at most one-half as strong as a-tocopherol and weaker than catechin. 

Yamaguchi F, Ariga T, Yoshimura Y and Nakazawa H. 2000. Antioxidative and anti-glycation activity of garcinol from Garcinia indica fruit rind. J Agric Food Chem 48(2) 180—185. 

Sang, S., Liao, C.H., Ran, M.H., Rosen, R.T., Shiau, S.Y.L., Lin, J.K. and Ho, C.T. (2002) Chemical studies on antioxidant mechanism of garcinol analysis of radical reaction products of garcinol with peroxyl radicals and their antitumor activities. Tetrahedron 58(51), 10095-10102. 

---