Gamma benzene hexachloride lotion

Heat items 2,4, and 5 to 95°C and pass through a stainless steel sieve. 

Dissolve item 1 in item 3 with stirring and add to step 2 at 35°C. 

Handbook of Pharmaceutical Manufacturing Formulations Semisolid Products 

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In a randomized trial a single oral dose of ivermectin (200 micrograms/kg) has been compared with 1% gamma-benzene hexachloride lotion for topical application overnight in 200 patients with scabies (16). The patients were assessed after 48 hours, 2 weeks, and 4 weeks. After 4 weeks, 83% showed marked improvement with ivermectin, compared with 44% of those treated with gamma-benzene hexachloride. There were no adverse events reported with gamma-benzene hexachloride. Headache was reported only once with ivermectin. 

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