Gallbladder cancer risk factors

The risk of gallbladder cancer is higher in patients having cholelithiasis or a calcified gallbladder and typhoid carriers, while ulcerative colitis is a clear risk factor for bile duct cancer. Patients having ulcerative colitis have an incidence of bile duct cancer that is 9-21 times higher than that in the general population. 

The risks and benefits of HRT should be carefully assessed on an individual basis. This is particularly important in women with predisposing risk factors, such as a personal or family history of deep vein thrombosis or pulmonary embolism, severe varicose veins, obesity or prolonged bed-rest [2], because HRT increases the risk of venous thromboembolism and stroke. HRT has also been observed to increase the risk of gallbladder disease, breast cancer and endometrial cancer. It is recommended that the minimum effective dose should be used for the shortest period of time, with treatment being reviewed at least once a year [2]. 

Kumar S. Infection as a risk factor for gallbladder cancer. / Surg Oncol. 2006 93 633-639. 

Increased weight increases cardiovascular risk factors, including hypertension, diabetes, and alterations in blood lipid levels. It also increases the risk for respiratory problems, gallbladder disease, and certain types of cancer. 

Today, the dietary "culprit" is fat. An estimated 35 million Americans are considered to be obese. Obesity is connected with a higher incidence of diabetes, hypertension, osteoarthritis, gallbladder disease, and some types of cancer. Additionally, high blood lipid levels are a major risk factor for heart disease. So, convenience and fast-food menus currently reflect consumer concern about the amount and type of dietary fat they are eating. For example, McDonald s "McLean Deluxe" is a low-fat ground beef patty that is 91% fat free, and contains only 310 calories and 1 0 grams of fat. 

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