Gabapentin Sodium valproate

A compound commonly used for treating epilepsy but also has applications in treating pain (e.g. phenytoin, carbamezapine, gabapentin and sodium valproate). 

Gabapentin is the most commonly used antiepilepsy drug in this setting phenytoin (which raises the threshold of nerve cells to electrical stimulation) or sodium valproate are used for resistant neuralgias. 

Individual drugs carbamazepine, phenytoin, sodium valproate, lamotrigine, vigabatrin, gabapentin, clonazepam, topiramate, levetiracetam. 

Bromide (1857) was the first drug to be used for the treatment of epilepsy, but it is now obsolete. Phenobarbital, introduced in 1912, controlled patients resistant to bromides. The next success was the discovery in 1938 of phenytoin (a hydantoin) which is structurally related to the barbiturates. Since then many other drugs have been discovered, but phenytoin still remains a drug of choice in the treatment of major epilepsy. Over the past ten years there has been a dramatic increase in the number of new anticonvulsant drugs (vigabatrin, gabapentin, lamotrigine, topiramate, oxcarbazepine, levetiracetam), but none has been shown to be superior to the major standard anticonvulsants (phenytoin, carbamazepine and sodium valproate). 

Gabapentin does not normally affect the pharmacokinetics of car-bamazepine, phenytoin, phenobarbital or sodium valproate, and no dosage adjustments are needed on concurrent use. However, isolated reports describe increased phenytoin levels and toxicity in two patients given gabapentin. 

Gabapentin does not affect phenobarbital levels, nor is it affected by pbenobarbital. Other studies confirm that the steady-state pharmacokinetics of carbamazepme and sodium valproate are unaffected by gabapentin, and that the pharmacokinetics of gabapentin are similarly unaffected by these antiepileptics. ... 

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