Gabapentin fatigue/somnolence

Gabapentin Dizziness Fatigue Somnolence Ataxia Pedal edema Weight gain... 

Systematic reviews In a systematic review of four randomized placebo-controlled studies of gabapentin in women with hot flushes after natural or tamoxifen-induced menopause, dropouts due to adverse events were more frequent in those who took gabapentin, particularly two adverse effects, dizziness/unsteadiness and fatigue/ somnolence [lll ]. 

Somnolence, dizziness, ataxia, fatigue, and nystagmus Discontinuation of gabapentin and/or addition of an alternative anticonvulsant drug to existing therapy should be done gradually over a minimum of 1 week... 

Gabapentin is effective only for partial seizures and secondary generalised epilepsy (not absence or myoclonic epilepsy), in combination with established agents. It is also used for neuropathic pain. Gabapentin may cause somnolence, imsteadiness, dizziness and fatigue. 

Two different regimens of add-on gabapentin have been compared in a double-blind, randomized trial (42). In 574 patients randomized to either slow initiation (300 mg on day 1, 600 mg on day 2, then 900 mg/day) or rapid initiation (900 mg/day immediately after the placebo lead-in), the four most common adverse events, which occurred equally in the two groups, were somnolence, dizziness, ataxia, and fatigue. The frequency of adverse events in a subgroup of elderly patients was similar to that in younger adults. 

Overall, gabapentin is well tolerated with the most common adverse effects of somnolence, dizziness, ataxia, and fatigue. These effects usually are mild to moderate in severity but resolve within 2 weeks of onset during continued treatment. 

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