Fatigue gabapentin

Gabapentin Dizziness Fatigue Somnolence Ataxia Pedal edema Weight gain... 

Somnolence, dizziness, ataxia, fatigue, and nystagmus Discontinuation of gabapentin and/or addition of an alternative anticonvulsant drug to existing therapy should be done gradually over a minimum of 1 week... 

Gabapentin is effective only for partial seizures and secondary generalised epilepsy (not absence or myoclonic epilepsy), in combination with established agents. It is also used for neuropathic pain. Gabapentin may cause somnolence, imsteadiness, dizziness and fatigue. 

The use of gabapentin has been reviewed (2). Its adverse effects are limited to neuropsychological disorders, namely dizzy spells, drowsiness, fatigue, and headache. The risk of interactions is also limited. 

Drowsiness, dizziness, fatigue, or ataxia are seen in 10-20% of patients who use gabapentin (SEDA-19, 70) (SEDA-20, 62) (10). Of 240 adults followed for about 1 year, only 4% discontinued treatment because of adverse events (SEDA-19, 70). Adverse effects... 

Two different regimens of add-on gabapentin have been compared in a double-blind, randomized trial (42). In 574 patients randomized to either slow initiation (300 mg on day 1, 600 mg on day 2, then 900 mg/day) or rapid initiation (900 mg/day immediately after the placebo lead-in), the four most common adverse events, which occurred equally in the two groups, were somnolence, dizziness, ataxia, and fatigue. The frequency of adverse events in a subgroup of elderly patients was similar to that in younger adults. 

Gabapentin has been of particular interest because it possesses a wide therapeutic index and a relatively benign side-effect profile. Side-effects reported with gabapentin are transient and minor, the most common being sortmolence, dizziness, ataxia and fatigue. It is not associated with hepatic or haematological problems. 

Overall, gabapentin is well tolerated with the most common adverse effects of somnolence, dizziness, ataxia, and fatigue. These effects usually are mild to moderate in severity but resolve within 2 weeks of onset during continued treatment. 

Adverse effects of gabapentin are uncommon and not serious. The CNS effects include mild to moderate sedation, fatigue, ataxia, headache, dizziness, and diplopia. Gabapentin may exacerbate myoclonus, but the effect is mild and does not require discontinuance of the drug (53,74). It has been associated with the development of neuropsychiatric adverse events in children. 

Systematic reviews In a systematic review of four randomized placebo-controlled studies of gabapentin in women with hot flushes after natural or tamoxifen-induced menopause, dropouts due to adverse events were more frequent in those who took gabapentin, particularly two adverse effects, dizziness/unsteadiness and fatigue/ somnolence [lll ]. 

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