GABA storage

Reetz A, Solimena M, Matteoli M, et al. (1991) GABA and pancreatic beta-cells colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion. In EMBOJ. 10 1275-84. 

There are numerous transmitter substances. They include the amino acids glutamate, GABA and glycine acetylcholine the monoamines dopamine, noradrenaline and serotonin the neuropeptides ATP and NO. Many neurones use not a single transmitter but two or even more, a phenomenon called cotransmission. Chemical synaptic transmission hence is diversified. The basic steps, however, are similar across all neurones, irrespective of their transmitter, with the exception of NO transmitter production and vesicular storage transmitter release postsynaptic receptor activation and transmitter inactivation. Figure 1 shows an overview. Nitrergic transmission, i.e. transmission by NO, differs from transmission by other transmitters and is not covered in this essay. 

Presynaptic drug effects can interfere with the metabolism, storage, release, and reuptake of GABA, as they can with the functioning of other neurotransmitters. 

Burger PM, Hell J, Mehl E, Krasel C, Lottspeich F, Jahn R (1991) GABA and glycine in synaptic vesicles storage and transport characteristics. Neuron 7 287-293. 

Szerb JC (1984) Storage and release of endogenous and labelled GABA formed from [- HJglutamine and [ CJglucose in hippocampal slices effect of depolarization. Brain Res 293 293-303. 

K.H. Kim, S. Gaba, D. Wheeler, J.M. Cruz-Albrecht, T. Hussain, N. Srinivasa, W. Lu, A functional hybrid memristor crossbar-array/CMOS system for data storage and neuromorphic applications. Nano Lett. 12 (2012) 389-395. 

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