GABA receptors distribution

Finally, neuroanatomical distribution of steroid-sensitive GABA, receptors in the CNS needs to be further correlated with CNS areas involved in anxiety responses as well as their interaction with other transmitter systems, for example, CRH or dopamine [Grobin et al. 1992 Zhang and Jackson 1994). Such characterization may result in the development of more specific compounds, possibly also involving concomitant antidepres-sive effects. 

GABAj receptors are of the seven-transmembrane G-protein-coupled type, and they have a widespread distribution in the body. Agonists at this receptor site include L-baclofen, CGP 27492 and CGP 35024. The receptors are negatively coupled to cAMP, and typical responses in neurons are to inhibit excitability by opening potassium channels or closing calcium channels. These inhibitory actions can be harnessed clinically for instance, baclofen is used as a muscle relaxant and has actions mainly at the spinal level within the GNS (see SKELETAL MUSCLE RELAXANTS). See GABA RECEPTOR ANTAGONISTS. 

The following sections review the distributions of glutamate and GABA receptors and gap junction proteins in the MOB. In some cases, additional details about the neurophysiology and functional significance of the receptors are provided in the layer-specific sections earlier. 

TABLE 3. Distribution of GABA receptor subunit mRNAs in rat cerebellum... 

Bristow DR, Martin IL (1988) Light microscopic autoradiographic localization in rat brain of the binding sites for the GABA receptor antagonist [ H]SR95531 comparison with pHJGABA, distribution. Eur. J. Pharmacol, 148, 283-288. 

Kingsbury AE, Wilkin GP, Patel AJ, Balazs R (1980) Distribution of GABA receptors in the rat cerebellum. 

Laurie DJ, Seeburg PH, Wisden W (1992) The distribution of 13 GABA, receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J. Neurosci, 12, 1063-1076. 

Bowery, N.G., Hudson, A.L. and Price, G.W. (1987) GABA, and GABA receptor site distribution in the rat central nervous system. Neuroscience. 20. 365-383. 

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