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GABA Gabaculine

There exists a large body of literature on the turnover of GABA in brain In this review I have recommended the use of specific GABA-T inhibitors, such as 7-vinyl-GABA, gabaculine, and aminooxyacetic acid, that can be administered either systemically or intracerebrally... [Pg.226]

The Km of the enzyme for GABA was lO M at 25°C. The enzyme was generally freshly prepared although it could be stored at -20°C dissolved in 0.1M Hepes buffer (pH 7.1) containing 5 mM dithiothreitol (DTT) for up to 2 weeks without appreciable loss of activity. Gabaculine and other inhibitors were usually prepared at... [Pg.129]

Fig. 7. Mechanism proposed for inactivation of GABA transaminase by gabaculine (8). Fig. 7. Mechanism proposed for inactivation of GABA transaminase by gabaculine (8).
Bernasconi R, Maitre L, Martin P, and Raschdorf F (1982) The use of inhibitors of GABA-transaminase for the determination of GABA turnover in mouse brain regions an evaluation of ammooxyacetic acid and Gabaculine. / Neurochem. 38, 57-66. [Pg.227]

Rando R. R and Bangerter F. W (1977) The in vivo inhibition of GABA transaminase by Gabaculine. Biochem Biophys Res Commun 76, 1276-1281. [Pg.234]

GABA, see butanoic add, 4-amino gabaculine, see cycIob a-l,3-diene-... [Pg.301]

Gabaculine, see l,3-Cyclohexadienyl-5-aminocarboxylic acid GABA transaminase, see v-Aminobuty-rate-a-ketoglutarate transaminase D-Galaotal, 26... [Pg.763]


See other pages where GABA Gabaculine is mentioned: [Pg.561]    [Pg.561]    [Pg.233]    [Pg.339]    [Pg.272]    [Pg.248]    [Pg.128]    [Pg.128]    [Pg.129]    [Pg.129]    [Pg.130]    [Pg.130]    [Pg.134]    [Pg.136]    [Pg.139]    [Pg.140]    [Pg.319]    [Pg.325]    [Pg.224]    [Pg.186]    [Pg.75]    [Pg.218]    [Pg.218]    [Pg.219]    [Pg.252]    [Pg.132]   
See also in sourсe #XX -- [ Pg.13 , Pg.509 , Pg.510 ]




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