G protein-coupled receptor microarray

Fang, Y., Lahiri, J., and Picard, L. (2003) G-protein-coupled receptor microarrays for drug discovery. Drug Discovery Today 8, 755-761. 

Keywords Microarray DNA microarray Carbohydrate microarray Protein microarray Antibody microarray G protein-coupled receptor microarray Cellular microarray Optical biosensor Resonant waveguide grating biosensor Surface plasmon resonance Dynamic mass redistribution... 

Fang Y, Peng J, Ferric AM, Burkbalter RS (2006) Air-stable G protein-coupled receptor microarrays and ligand binding characteristics. Anal Chem 78 149-155... 

Fang Y, Webb B, Hong Y (2004). Fabrication and application of G protein-coupled receptor microarrays. Methods Molec. Biol. 264 233-243. 

Protein assays using ordered arrays emerged in the late 90s [13]. Recently Lahiri et al. introduced a technique which enables the fabrication of microarrays for membrane proteins [14]. Printed lipid microspots on y-aminopropylsilane slides have high mechanical stability, independent of whether the lipid is in the gel-or fluid-phase. They immobilized G-protein coupled receptors and studied their interaction with a set of inhibitors. 

G-protein-coupled receptors (GPCRs) currently make up the largest class of therapeutic drug targets and are an obvious choice for microarray-based drug... 

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