GRK, G-protein-coupled receptor kinase

G-protein-coupled receptor kinases (GRKs) are a family of enzymes that catalyze the phosphorylation of threonine or serine residues on G-protein-coupled receptors. Characteristically, GRKs only phosphorylate the ligand-activated form of the receptors. Phosphorylation by GRKs usually leads to impaired receptor/G-protein coupling. 

G-protein-coupled Receptor Kinases (GRKs) G-protein-coupled Receptors... 

Homologous desensitization is a form of desensitization which is mediated by agonist-induced activation of the same receptor. G-protein-coupled receptor kinases (GRKs) and arrestins are involved in this process, which leads to an uncoupling of the receptor from its G protein. 

G-protein-coupled Receptor Kinases (GRKs) G-protein-coupled Receptors G-proteins and Wnt Signaling Granulocyte-CSF (G-CSF) Granulocyte-macrophage-CSF (GM-CSF)... 

A major mechanism of desensitization that occurs rapidly involves phosphorylation of receptors by members of the G protein-coupled receptor kinase (GRK) family, of which there are seven members. Specific adrenoceptors become substrates for these kinases only when they are bound to an agonist. This mechanism is an example of homologous desensitization because it specifically involves only agonist-occupied receptors. 

Dean, K.R. Akhtar, M. Novel mechanism for the activation of rhodopsin kinase Implications for other G protein-coupled receptor kinases (GRK s). Biochemistry, 35, 6164-6172 (1996)... 

G protein-coupled receptor kinases (GRKs) 441 scaffold proteins 441 inhibitory G protein (GO 441 calmodulin (CaM) 444 Ca2+/calmodulin-dependent protein kinases (CaM kinases I IV)) 444 two-component signaling systems 452 receptor His kinase 452 response regulator 452 receptorlike kinase (RLK) 455... 

Ribas C, Penela P, Murga C, Salcedo A, Garcfa-Hoz C, Jurado-Pueyo M, Aymerich I, Mayor F Jr (2007) The G protein-coupled receptor kinase (GRK) interactome role of GRKs in GPCR regulation and signaling. Biochim Biophys Acta 1768(4) 913-922... 

Ligand-dependent differences in relative efficacy to promote desensitization of different responses coupled to the same receptor could be the result of differences in the ability to activate desensitization mechanisms for each response. Alternatively, ligand-specific receptor conformations could serve differentially as targets for desensitization mechanisms that target the receptor. It is known that some desensitization mechanisms, such as G protein-coupled receptor kinase (GRK) and arrestin, appear to be sensitive to receptor conformation... 

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