G.D. Searle

A similar procedure may be used for the preparation of /)-cyanobenzaldiacetate from -tolunitrile. Information submitted by Rorig and Nicholson, of G. D. Searle and Company, indicates that the critical step in this preparation is to maintain the reaction temperature below 10° throughout the process. Exposure of -cyanobenzaldiacetate to excess chromic, acetic, and sulfuric acids causes a reduction in yield. During the oxidation care should be taken to prevent chromium trioxide from adhering to the walls of the flask above the reaction mixture and then dropping in large amounts into the solution. 

D. W. Houghton, G. D. Searle and Company Ltd., High Wycombe, Bucks,... 

Other Food Industries. Aspartame is a synthetic dipeptide ester, L-asp-L-phe-OMe which is about 200 times as sweet as sucrose. It has recently been released for sale in North America and Europe by G. D. Searle. It was originally synthesized chemically and reported by Mazur et al. 38). Subsequent improved methods of synthesis have been developed which involve the use of metalloproteases such as thermolysin in reverse . Metalloproteases are used because, unlike the more common proteases, they have no esterase activity. 

Aspartame is a high intensity dipeptide sweetener, ca. 200 times as sweet as sncrose. It was originally developed by G.D.Searle Co. prior to their acqnisition by Monsanto. Chemically synthesised aspartame has rapidly acqnired a major share of the world high intensity sweetener market, particnlarly in soft drinks. Until recently it has all been snpplied by a monopoly snpplier, the Nntrasweet Corp (a Monsanto-AJinomoto joint ventnre) protected by prodnct patents. Recently biocatalytic methods... 

To the memory of now-defunct laboratories where once I practiced my craft Building H at G.D. Searle in Skokie, Upjohn s Building 25 in Kalamazoo and the diminutive Chemistry Annex at the Adria Laboratories just outside Dublin, Ohio. 

Pfizer merges with Pharmacia, which had earlier merged with Upjohn and G. D. Searle. 

---