G-CSFR

Fig. 11.2. Domain structure of cytokine receptors. Schematic representation of the domain structure of selected cytokine receptors. WS motif conserved WSXWS sequence (W tryptophan S serine X non-conserved amino add) IL interleukin EpoR receptor for erythropoietin GHR growth hormone receptor LIF-R leukemia inhibitory factor receptor G-CSFR granulocyte colony stimulating factor receptor IFNR interferon receptor TNFR tumor necrosis factor receptor NGFR nerve growth factor receptor Fas, CD40 transmembrane receptors of lymphocytes.

Fig. 11.3. Subunit structures of cytokine receptors. EpoR and G-CSFR have a homo-oligomeric structure. The other receptors shown are composed of different subunits, some of which occur in several receptors. The gpl30 subunit is common to IL-6R and LIF-R the Yc subunit is found in IL-2R and IL-4R. The subunits, at which ligand binding occurs, are indicated by arrows. LIF-R leukemia inhibitory factor receptor.

The first edition of the book was drafted with respect to the limited extent required by the publishers. This requirement is also the case for the second edition. Therefore the insertion of new results dictated the omission of some sections, e. g. of a part of the text specific for CSFR, of the chapter on the sources and toxicity of monomers, and of whole part 9 on the methods of polymer investigation. The general concept of the book has not changed its aim is to inform on all important findings, to facilitate the search for the common features of any of the various basic polymerization processes, without distracting the reader s attention by a too detailed description of some special cases isolated in the context. 

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