Fyrquel

Rat (Fischer- 344) 90 d 10.1 100 (kyphosis, decline in tail tip curl) MacEwen and Vernot 1983 Fyrquel 220... 

Single 4-hour exposures to aerosols of U.S. military fluids Durad MP280 and Fyrquel 220 produced no deaths in male rats at respective concentrations of 6,190 and 5,790 mg/m3 and female rats exposed to 6,350 and 6,310 mg/m3, respectively (Gaworski et al. 1986 Kinkead et al. 1992a). Daily 4-hour exposures over an 11-day period caused death to a single rabbit exposed to 2,000 mg/m3 of Cellulube 220 (Carpenter et al. 1959). 

Aerosols of Cellulube 220 produced deaths associated with severe dyspnea and mild diarrhea in one of two rabbits exposed to 2,000 mg/m3 for <4 hours/day, 5 days/week for 11 or 22 days (Carpenter et al. 1959). Continuous exposure for 30-160 days to aerosols of a triaryl phosphate U.S. military hydraulic fluid (see Table 3-2), at concentrations <110 mg/m3, produced no deaths in dogs or rats, but deaths associated with severe neurotoxic symptoms occurred in chickens exposed to concentrations >23 mg/m3 and in rabbits exposed to 102 mg/m3 (Siegel et al. 1965). Aerosols of Durad MP280 or Fyrquel 220 (continuous exposure for 90 days) produced no deaths in rats or hamsters exposed to 100 mg/m3. Deaths associated with lethargy, cachexia, and head droop occurred in rabbits exposed to 101 mg/m3 Durad MP280, but not in rabbits exposed to 100 mg/m3 Fyrquel 220 (MacEwen and Vemot 1983). Some of the Durad MP280-exposed rabbits were also infected with Pasteurella, which may have contributed to neurological symptoms. No deaths occurred in rats exposed to cyclotriphosphazene at 990 mg/m3, 6 hours/day,... 

In animals, the only musculoskeletal effect observed was kyphosis, a deformity of the spine characterized by extensive flexion. Kyphosis was observed in rats exposed to 100 mg/m3 of Fyrquel 220 and 101 mg/m3 of Durad MP280 for an intermediate duration (MacEwen and Vemot 1983). The kyphosis was not observed at 10 mg/m3. It is not known whether the kyphosis was due to neurological or musculoskeletal... 

MP280 (continuous exposure for 90 days) produced kyphosis (a deformity of the spine characterized by extensive flexion) and a decrease in the tail tip curl reflex in rats and anorexia, lethargy, cachexia, and head droop in rabbits after exposure to 101 mg/m3 exposure to 10.3 mg/m3 produced no signs of neurotoxicity in these species (MacEwen and Vemot 1983). Hamsters similarly exposed to 101 mg/m3 Durad MP280 showed no evidence of neurotoxicity in this study. Aerosols of Fyrquel 220 (continuous exposure for 90 days) likewise produced kyphosis in rats at 100 mg/m3, but no clinical signs of neurotoxicity in rabbits or hamsters at 100 mg/m3 (MacEwen and Vemot 1983). Because of the uncertainty that the kyphosis observed in rats is a neurological or muscular effect, this effect has been discussed in both sections. 

Testicular atrophy was observed upon gross necropsy after male rats were continuously exposed for 90 days to an aerosol concentration of 101 mg/m3 Durad MP280, but not in rats exposed to 10.3 mg/m3 (MacEwen and Vemot 1983). Testicular atrophy was not observed in male rats continuously exposed for 90 days to an aerosol concentration of 100 mg/m3 Fyrquel 220 (MacEwen and Vemot 1983). 

Likewise, no treatment-related gross reproductive tract alterations after intermediate-duration exposure were observed in male or female rabbits or in male hamsters continuously exposed to aerosols of Fyrquel 220 at concentrations <100 mg/m3 (MacEwen and Vemot 1983). Two male rabbits exposed for 1-4 hours/day, 4-5 days/week, for 11-26 days to 2,000 mg/m3 aerosol of Cellulube 220 (Carpenter et al. 1959) showed no histological evidence for effects on reproductive tissues. No acute or chronic inhalation studies examining reproductive effects in animals were located. 

Rat (Sprague- Dawley) once (GO) Resp Gastro Bd Wt 5750 5750 5750 (diarrhea) Gaworski et al. 1986 Kinkead et al. 1992a Fyrquel 220... 

Cow (Hereford Charolais) once (G) 500 (miosis, salivation, coma, convulsions, decreased blood cholinesterase, axonal degeneration, paralysis) Beck et al. 1977 Fyrquel 150... 

Chicken (White Leghorn) 5 d (GO) 240 F (severe paralysis) Stauffer Chemical 1971 Fyrquel 150... 

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